This one completely changed my skin texture in about three weeks. My fine lines around the eyes look noticeably softer and less severe. It feels super smooth applying it every evening, and best of all, zero irritation or flaking!
PureGlow — Prime Series for Women 40+
PureGlow — Prime Series for Women 40+
Skin That Reflects How You Actually Feel
Skin renews more slowly over time. Texture, tone, and firmness are usually the first places it shows.
PureGlow pairs retinol with Hexapeptide-11 to support the look of firmness and a more even, refined complexion, balanced by bisabolol and phospholipids so the formula stays comfortable to use nightly. Carefully selected and aligned with the skin priorities of life after 40.
Choosing to invest in your skin today is part of a broader, more intentional approach to understanding and supporting your health after 40.
For external use only. Fragrance free, paraben free, sulfate free. Vegan and cruelty free. If pregnant or nursing, consult your physician before use.
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30 day money-back guarantee
Free US shipping
Carefully selected ingredients
Key Benefits
- Supports the look of firmness and a more even, refined complexion
- Retinol paired with Hexapeptide-11, balanced by bisabolol
- Aligned with the skin priorities of women 40+
- Vegan, cruelty free, fragrance free, paraben free, and sulfate free
- Manufactured in the USA
- Connects with the broader LEAN approach to supplements, health insights, and living well after 40
Key Ingredients
Retinol: known for its smoothing properties, supporting refined texture and a more even looking complexion.
Hexapeptide-11: a peptide that works alongside retinol to support the look of skin firmness.
Phospholipids: nourishing lipids that help the serum absorb quickly without feeling heavy.
Bisabolol: a soothing ingredient that supports a soft, balanced feel and complements retinol.
Full ingredient list is shown in the Ingredients section above.
How to Use
Apply 3 to 4 drops to face and neck at night after cleansing. Follow with moisturizer. Use sunscreen the following morning, as retinol may increase skin sensitivity to sunlight.
If using HydraFirm, apply HydraFirm first, then PureGlow.

Retinol supports the look of smoother texture and a more even complexion over time.
Skin That Keeps Up
Hexapeptide-11 works alongside retinol to support the look of firmness.
Support for Smoother Looking Skin
Bisabolol and phospholipids keep the formula comfortable enough to use nightly.
Refined and Even
Your Daily Routine

Begin your routine
Apply 3 to 4 drops to face and neck at night after cleansing.

Make it automatic
Apply it at the same point in your evening skincare routine.

Give it the best conditions
Follow with moisturizer. Use sunscreen the next morning, as retinol increases sun sensitivity.

Pay attention to the fit
Notice how the product fits with the rest of your skincare routine.

Support the bigger picture
Use it as one part of a consistent skincare routine that includes cleansing, moisturizing and daily sun protection.
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FAQ
How are LEAN formulas developed?
Our formulas use carefully selected ingredients at meaningful doses, manufactured in the USA in an FDA registered facility following cGMP standards. We do not claim our finished formulas have been through clinical trials, because they have not. We choose ingredients with published research behind them, at doses consistent with that research, and disclose exactly what is in every bottle.
How do I know which series is right for me?
Prime is formulated for the priorities of life after 40. Platinum is formulated for after 50. The formula is the same within a product; the series reflects the stage of life the guidance is written for. Choose the one that matches where you are.
How should I take this?
Directions are on the product label and in the How to Use section above, since they differ by product. Follow the label.
Is it safe to take with other supplements or medications?
Talk to your doctor or pharmacist before combining supplements, particularly if you take prescription medication. That is true of any supplement, including ours.
What is in it, exactly?
The full Supplement Facts panel and Other Ingredients list are shown on this page. Some formulas use a proprietary blend, where the total is disclosed but individual amounts are not. Where that applies, the panel says so.
Do you have allergens?
Allergen information is listed on every product page. OmegaPure contains fish. FocusFlex contains soy and fish. Some capsules are gelatin based and are not suitable for vegetarians. Check the product page before ordering.
Where do you ship and how long does it take?
We ship across the United States. Orders are fulfilled within one to two business days and typically arrive within three to seven days.
What if it is not right for me?
We offer a 30 day money back guarantee. If it does not suit you, contact Support@LeanNutraceuticals.com and we will make it right.
Customer Reviews
Overall rating: 4.8 / 5 from 282 reviews.
This one completely changed my skin texture in about three weeks. My fine lines around the eyes look noticeably softer and less severe. It feels super smooth applying it every evening, and best of all, zero irritation or flaking!
Isabella 5/5
Absolutely in love with PureGlow! After turning 42, my skin felt dull and lacked that healthy bounce. This serum brought back a natural radiance that I haven't seen in years.
Karen 5/5 Verified
Absolutely in love with PureGlow! After turning 42, my skin felt dull and lacked that healthy bounce. This serum brought back a natural radiance that I haven't seen in years.
Karen 5/5
Absorbs quickly without any sticky residue left on my pillow. My skin tone looks much more even after 3 weeks of nightly use. Will definitely be reordering!
Sophia 5/5 Verified
This serum has become the centerpiece of my nightly routine. The combination of retinol and hexapeptide-11 really works wonders for skin firmness. My jawline and cheeks feel so much tighter and well-hydrated. Highly recommend it for any woman over 40!
Beverly X. 5/5 Verified
Absorbs quickly without any sticky residue left on my pillow. My skin tone looks much more even after 3 weeks of nightly use. Will definitely be reordering!
Sophia 5/5
This serum has become the centerpiece of my nightly routine. The combination of retinol and hexapeptide-11 really works wonders for skin firmness. My jawline and cheeks feel so much tighter and well-hydrated. Highly recommend it for any woman over 40!
Beverly X. 5/5
I've been using this for two months now and the results speak for themselves. My husband even commented on how glowing my skin looked last week! It's gentle enough for daily use and layers perfectly under my night cream.
Diane D. 5/5 Verified
I've been using this for two months now and the results speak for themselves. My husband even commented on how glowing my skin looked last week! It's gentle enough for daily use and layers perfectly under my night cream.
Diane D. 5/5
Really solid night serum that doesn't dry out my sensitive skin like traditional retinol products usually do. The only reason I gave 4 is that the pump bottle sometimes dispenses a bit too much product if you aren't careful. Otherwise, my skin looks firmer and much more even after a month.
Carolyn 4/5 Verified
Really solid night serum that doesn't dry out my sensitive skin like traditional retinol products usually do. The only reason I gave 4 is that the pump bottle sometimes dispenses a bit too much product if you aren't careful. Otherwise, my skin looks firmer and much more even after a month.
Carolyn 4/5
Finally a retinol formula designed for mature skin that doesn't cause peeling! My face feels calm, nourished, and visible lines around my mouth are slowly fading away.
Victoria 5/5 Verified
PureGlow is pure magic in a bottle. Within ten days, the texture of my forehead and cheeks smoothed out dramatically. My makeup glides on so much smoother in the morning now.
Sarah 5/5 Verified
Finally a retinol formula designed for mature skin that doesn't cause peeling! My face feels calm, nourished, and visible lines around my mouth are slowly fading away.
Victoria 5/5
PureGlow is pure magic in a bottle. Within ten days, the texture of my forehead and cheeks smoothed out dramatically. My makeup glides on so much smoother in the morning now.
Sarah 5/5
I started using 3-4 drops every night as directed and followed up with my usual moisturizer. The difference in skin elasticity and brightness is amazing. Never going back to drugstore serums again!
Shirley_style 5/5 Verified
I started using 3-4 drops every night as directed and followed up with my usual moisturizer. The difference in skin elasticity and brightness is amazing. Never going back to drugstore serums again!
Shirley_style 5/5
Gentle yet extremely effective. No redness or burning at all!
Jessica 5/5 Verified
Good serum that delivers gradual results. It took about a full month before I started seeing a real change in skin firmness, but my face definitely feels softer and looks less tired. Wish the bottle was slightly larger for the price, but quality is high.
Ann L. 4/5 Verified
Gentle yet extremely effective. No redness or burning at all!
Jessica 5/5
Good serum that delivers gradual results. It took about a full month before I started seeing a real change in skin firmness, but my face definitely feels softer and looks less tired. Wish the bottle was slightly larger for the price, but quality is high.
Ann L. 4/5
Being 46, my skin was starting to look tired and lose its tightness. PureGlow revived it completely. The peptide complex alongside retinol really gives it an extra punch for firmness. I look well-rested even when I'm running on four hours of sleep!
Cheryl 5/5 Verified
Being 46, my skin was starting to look tired and lose its tightness. PureGlow revived it completely. The peptide complex alongside retinol really gives it an extra punch for firmness. I look well-rested even when I'm running on four hours of sleep!
Cheryl 5/5
Lightweight texture, neutral smell, and incredible results. My sunspots are fading nicely and my complexion feels deeply hydrated every morning when I wake up.
Jean Q. 5/5 Verified
Lightweight texture, neutral smell, and incredible results. My sunspots are fading nicely and my complexion feels deeply hydrated every morning when I wake up.
Jean Q. 5/5
Unfortunately, this product did not work well for my skin. Even though it claims to be gentle, my face developed slight redness and tiny bumps after three nights of application. It might just be an allergy to one of the botanical ingredients, but I had to return it.
Patricia_13 2/5 Verified
Decent serum overall. It definitely hydrated my skin and didn't cause any redness, which is a major plus for my reactive face. However, I haven't noticed a huge reduction in my deeper wrinkles yet after four weeks of daily use. Might need more time.
Andrea G. 3/5 Verified
Unfortunately, this product did not work well for my skin. Even though it claims to be gentle, my face developed slight redness and tiny bumps after three nights of application. It might just be an allergy to one of the botanical ingredients, but I had to return it.
Patricia_13 2/5
Decent serum overall. It definitely hydrated my skin and didn't cause any redness, which is a major plus for my reactive face. However, I haven't noticed a huge reduction in my deeper wrinkles yet after four weeks of daily use. Might need more time.
Andrea G. 3/5
Fantastic product for women over 40. Smooths out fine lines without drying out the skin barrier.
Charlotte_girl81 5/5 Verified
Fantastic product for women over 40. Smooths out fine lines without drying out the skin barrier.
Charlotte_girl81 5/5
I noticed a smoother skin surface within the first week. The bisabolol really calms down any potential retinol irritation. My face looks radiant every morning!
Sharon 5/5 Verified
I noticed a smoother skin surface within the first week. The bisabolol really calms down any potential retinol irritation. My face looks radiant every morning!
Sharon 5/5
Works exceptionally well on age spots and fine creasing around the cheeks. I pair it with SPF 50 during the day as recommended, and my face looks clearer and brighter than it did five years ago!
Chloe D. 5/5 Verified
Works exceptionally well on age spots and fine creasing around the cheeks. I pair it with SPF 50 during the day as recommended, and my face looks clearer and brighter than it did five years ago!
Chloe D. 5/5
Nice lightweight formula that absorbs within seconds. It has helped fade some minor discoloration on my cheeks, though deeper lines around my eyes haven't changed much yet. Still a very enjoyable product to use every night.
Jennifer 4/5 Verified
This serum is worth every penny. My skin feels firm, supple, and healthy.
Jennifer J. 5/5 Verified
Nice lightweight formula that absorbs within seconds. It has helped fade some minor discoloration on my cheeks, though deeper lines around my eyes haven't changed much yet. Still a very enjoyable product to use every night.
Jennifer 4/5
This serum is worth every penny. My skin feels firm, supple, and healthy.
Jennifer J. 5/5
